<![CDATA[Treffert Innovations - Blog]]>Wed, 01 May 2024 21:19:06 -0400Weebly<![CDATA[A bit OF a Detour]]>Wed, 01 May 2024 20:03:59 GMThttp://treffertinnovations.com/blog/a-bit-of-a-detour
I set out on one of my beautiful rural road bike routes on the early evening of Monday April 22.  The next memory I have is waking up in the Emergency Department of the University of Tennessee Medical Center- from which I pieced together how I arrived there.
I ride with my cell phone and use the Beacon feature of the Strava app which allows my wife to follow my progress on her phone - which stopped about half way through.  She called my phone and reached a very  kind Good Samaritan (actually one of at least two) who found me unconscious by the side of the road and called the police who in turn called an ambulance.
The police report indicates that I stated that I fell off my bike on West Bull Run Valley but could not describe why.  I'm told I was repeating myself a bit.  I was happy to see that the UTMC documents at least referred to a " very pleasant 67-year-old male" and "a good historian". 
I had a series of physical and mental examinations which yieled no remarkable suprises to attend to.  At 10 PM a CT's of neck, chest adbomen and pelvis were unremarkable - however CT of the head revealed:
      Subarchnoid hemorrage
      Subdural hematoma
in addition to face lacerations and scraping of the hands and side.  I was scheduled for a follow up at 4 AM to see if my situation would stabilize and allow me to be discharged.
On return to my room - my wife and I settled down to a long series of "Murder She Wrote" episodes on my TV.  I was then wheeled in for a second CT without contrast:
I was then discharged and Kathy drove us home.  I had a bit a room-spinning when rising from sleep which is subsiding.  My wounds are scabbing over.  Soon I'll bring my bike in for a once over and see if I'm ready to get back in the saddle.
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<![CDATA[More GooD NEWS]]>Sat, 23 Mar 2024 01:40:04 GMThttp://treffertinnovations.com/blog/march-22nd-2024
In January I drew blood for a new molecular residual disease test - Signatera . The test detects circulating tumor DNA.   The first results take about 8 weeks because genetic analysis of your tumor is needed to inform the analysis.  The predictive power for treatment response appears quite impressive.
I was informed today that my test results are negative - which combined with the news from the previous post would indicate that my first line treatment is working very well.
I am scheduled to begin a 6th cycle of treatment (Keytruda/Padcevv) next Friday and will discuss next steps with my medical oncologist.
In addition to hair loss, I've started to have a runny nose and a bit of taste change.  Claritin did a fine job of clearing up the runny nose.
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<![CDATA[FirST Follow up - Good News]]>Sat, 09 Mar 2024 21:14:56 GMThttp://treffertinnovations.com/blog/first-follow-up-good-news
On March 6, 2024 I had a first PET/CT follow-up after 4 cycles of treatment with a combination of Keytruda and Padcev.  It took a bit of courage to press the button on my patient portal to bring up the radiology report which was available the next day.  My first PET/CT on November 11, 2023 showed very active pelvic  lymph nodes and changed my staging up to Stage 3 or 4 disease.
The news couldn't have been much better - the lymph nodes were no longer showing evidence of disease and there was no evidence of further spread.  As noted in the previous post when I had surgery in January no evidence of recurrence of the primary tumor was seen inside the bladder.

I attribute this to God's grace:
By the skills and persistence of those who developed my cancer treatment.
By those who participated in clinical trials to motivate accelerated approval of this treatment by the FDA.
By Medicare which allows me to afford and take advantage of this treatment
By my care team at the University of Tennesse Cancer Institute who arranged for and guide my treatment.
By my fasting regimen which I believe minimized adverse effects of treatment and may have contributed to treatment efficacy.
By the privilege to participate in the development of PET/CT at CTI/Siemens which found and monitors the presence of my cancer.
By prayers offered for me by so many family and friends and my church family.

I will continue treatment to see if my response is durable.  In January I gave a blood sample to run a new test - Signatera.  The first test uses DNA from resected tumor to inform bloold analysis which detects circulating tumor DNA to identify if there is any molecular evidence of residual disease.  This will complement my next follow up PET/CT.



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<![CDATA[Fasting, EXERCISE AND MY CANCER REGIMEN]]>Thu, 08 Feb 2024 00:45:05 GMThttp://treffertinnovations.com/blog/fasting-exercise-and-my-cancer-regimen I was introduced to the health benefits of intermittent and periodic extended fasting and green exercsise during my health journey to reverse type 2 diabetes (see earlier posts).  While developing a proton therapy system I learned that fasting and exercise can reduce the adverse effects of radiation and chemotherapy  for cancer.

One component of my therapy is Padcev (see previous entry) - which delivers a cancer killing agent MMAE to cells (like my cancer cells) which express a protein Nectin 4.  Some studies have suggested that fasting may enhance the sensitivity of cancer cells to stress, while protecting normal cells from stress. This phenomenon is called differential stress sensitization (DSS). Fasting may induce DSS by lowering the levels of growth factors and hormones, such as insulin and IGF-1, that promote the survival and proliferation of cancer cells. Fasting may also induce DSS by activating a process called autophagy, where the cells recycle their damaged or unwanted components. Autophagy may help normal cells to cope with stress and remove toxic substances, while cancer cells may fail to perform autophagy properly and accumulate more damage.

The other component of my therapy is Keytruda (see previous entry) which boosts my immune response.  Studies have suggested that fasting may enhance the efficacy of cancer immunotherapy by boosting the immune system, increasing the immunogenicity of the tumor, and alleviating the immunosuppression caused the the tumor or chemotherapy.

I found green exercise - in my case e-biking on local roads - in addition to reducing stress and improving mode was also help in reducing insulin resistance and inflammation.  It may also boost the immune system and also enhance the effectiveness of chemotherapy and immunotherapy.

My regimen:
I begin fasting 2 days before my infusion, fast on the day of infusion and 2 days after.  The extended fasting induces autophagy.  The clearance half time for the cancer killing component of Padcev (MMAE) is 2.4 days. Fasting 2 days after infusion maintains maximal protection of normal cells and stress on cancer cells while the chemotherapy agent is most active.

I then keep my carbohydrate consumption low enough to maintain nutritional ketosis between infusions.  This helps to minimize the fuel source used by cancer low.

I continue to ride my e-bike at least 2-3 times a week which, as always is a great for stress relief, mood elevation and glucose control.

Results so far:
Other than losing a fair bit of hair, I have had no adverse effects from treatment.
I had surgery in January to remove a stent placed in my right ureter during a procedure to resect my primary tumor.  No evidence of the primary tumor was seen and my right kidney function was brisk so the stent was not replaced.

I am in my third cycle of treatment and on completion of the fourth I will have another PET/CT exam which will show whether treatment has been effective.

I would like to see more clinical trials designed to demonstrate and assess the benefits of fasting and exercise in cancer treatment and will be seeking opportunities to participate in such work.

References:

Fasting and cancer: Benefits and effects
Adding fasting-mimicking diet to first-line carboplatin-based chemotherapy is associated with better overall survival in advanced triple-negative breast cancer patients: A subanalysis of the NCT03340935 trial
Short-Term Fasting Synergizes with Solid Cancer Therapy by Boosting Anti-tumor immunity

A review of fasting effects on the response of cancer to chemotherapy
Fasting and Exercise in Oncology: Potential Synergism of Combined Interventions
Researchers Look to Fasting as a Next Step in Cancer Treatment
Effect of fasting on cancer: A narrative review of scientific evidence​
Fast-Mimicking Diet is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer
Safety and Feasibility of Fasting-Mimicking Diet and Effects on Nutritional Status and Circulating Metabolic and Inflammatory Factors in Cancer Patients Undergoing Active Treatment







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<![CDATA[Treatment BEGINS]]>Wed, 07 Feb 2024 16:17:29 GMThttp://treffertinnovations.com/blog/treatment-beginsNovember 29, 2023 -  My Social Security and Medicare application was approved.  Medicare was retroactive to desired start date of Nov 1 in by October application.  Because of the delays, I paid for 1 month of (very expensive) COBRA extension of my former employer insurance to cover any claims in November.   I notified my providers at the University of Tennessee Medical Center of my new coverage and prepared to start first treatment on Dec 7.   Somehow the new coverage didn't make it through the system.  I had a bit of anticipation and anxiety regarding delivery and adverse effects of treatment and was quite crestfallen to learn that the treatment would not begin that day.  It  had been 2 months since my TURBT surgery.

At the same time - had I proceeded earlier the treatment options afforded by standard of care based on information at the time - Radical Cystectomy  or Trimodality Therapy would have been quite different.  My wife and I spent our nervous energy and disappointment on retail therapy - we had lost our home to first on March 29 and decided to shop for some furniture and appliances to populate a new manufactured home we had recently ordered to replace it.

Dec 11:   I was introduced to the mechanics of my first line treatment:  Prior to any treatment, I have two tu es of blood drawn and the lab results are reviewed to determine that there is no indication that would prevent adminstration.  At the beginning of each cycle I meet with my medical oncologist and he would give the go ahead to proceed with a treatment cycle.  Two hours are allocated for the blood work and consultation.

I then proceed to the infusion center waiting room.  When they are ready I am called back to one of several suites of rooms with chemo chairs: recliners with side tables on each arm.  I choose an available seat and wait for the pharmacy to give a green check for preparation of the iv bags of the agents to be infused.  I am offered a warm blanket as I settle in and blood pressure is taken. When the green check from the pharmacy arrives, a nurse looks for a place to insert a needle for an IV line.  Ideally the first insertion is functional - otherwise the needle is removed and another site chosen and tried.  The IV line is connected to a bag with saline.  When the agents are prepared they are brought in.  I first receive a syringe push of Kytril.  On first day of the cycle I receive an infusion of Keytruda and then an infusion of Padcev - each taking 30 minutes to complete.  On completion my blood pressure is taken and I am free to go..]]>
<![CDATA[DID NOT SEE CANCER COMING]]>Tue, 23 Jan 2024 18:04:42 GMThttp://treffertinnovations.com/blog/did-not-see-cancer-comingSeptember 21, 2023: after finding blood in my urine, my general practitioner arranged for a CT scan without contrast which indicated possible bladder cancer and hydronephrosis of the right kidney

September 22: A cystopic exam exam confirmed the a tumor in the bladder near the junction with the right ureter.   A surgery was scheduled but was delayed because the urologist was not in my insurance network.  I was then recommended to a urologist at the University of Tennessee Medical Center here in Knoxville

Oct 4:  I met with my urologist.   He was departing for longstanding vacation in Europe and recommended a colleague to perform surgery.

October 6:  A Transurethral Rescection of the Bladder Tumor (TURBT) surgery was performed.  It is an endoscopic procedure where the tumor in the bladder is "scraped" from the wall and samples removed for identifying the pathology.  The primary tumor was at the junction of the bladder and right ureter and was restricting flow from the right kidney.  A stent was placed in my right ureter.  Pathology confirmed that the cancer was muscle invasive urothelial carcinoma.

After reviewing standard of care options, I decided that I would focus on my treatment and recovery.   Being 65 would resign from my job effective Oct 31, apply for Social Security benefits and Medicare part B.  

Oct 18:  My urologist returned from vacation.  We discussed options - one of which was radical cystectomy (removal of bladder and likely nearby lymph nodes and potentially prostate and seminal vesicals) either preceded by or followed with a round of chemotherapy.   This is a current standard of care option for muscle invasive bladder cancer (MIBC) if it has not locally advanced or metstatic.  Imaging was scheduled for assessing spread/stage.  

Oct 26:  I met my medical oncologist.  The literature indicated that for muscle invasive bladder cancer which is not locally advanced or metastatic, surgery followed by radiation with neoadvujant chemotherapy has results equivalent to the the radical cystectomy.  This is referred to as trimodality therapy.  My oncologist agreed that this was a valid alternative.   Having led software development for proton therapy system - I knew that this was my radiation therapy modality of choice.  In Tennessee, reimbursement for proton therapy is limited - but can be approved by Medicare.  I wanted to consult with the local proton therapy facility before deciding on a course of action.  

Oct 30:  I had several imaging procedures:
    Lung CT Scan without contrast
    Pelvic CT with and without contrast
    Pelvic MR with contrast were performed.
 
These anatomical scans did not indicate loco-regional or metastatic spread of the disease.  A small lesion was found in the lung along with calcification in the coronary arteries.  I was aware of the calcification from a Coronary Artery Calcification scan I arranged after I had lost 100 lbs in my earlier health journery.  I have been pursuing aggressive lipid lowering to undo damage done by years of type 2 diabetes.

My Social Security and Medicare application still had not been approved so I decided to pay exorbinant fee for COBRA extension of my employer coverage which would end the next day to cover medical expenses in November.

Nov 2:  I had a consultation at the local proton therapy center and the radiation oncologist confirmed that they had done bladder cancer treatment and could do so with Medicare.  We scheduled a CT simulation in preparation for treatment planning.

Nov 10:  20 years after leading software development of first generation of Siemens PET/CT scanners (including working with clinical staff at the University of Tennessee) - I had my first PET/CT exam.  Unfortunately this exam showed significant PET activity in two pelvic lymph nodes near the bladder indicating loco-regional spread.  There was no indication of metastatic disease.  However, data on the use of radiation and chemotherapy on disease with locoregional spread was limited.  I soon had a call from my old boss at ProNova who informed me of progress that had been made at our first clinical installation in Nashville - including the precision delivery to lymph nodes.  I arranged for a consulation at the Nashville proton center.  It was approaching 4 weeks after I had applied for Social Security and Medicare Part B.  My wife had applied after I did and her application was approved in two weeks.  I was relying on having Medicare in place to have proton therapy approved.

I had been continually surveying the literature and discovered that a promising new treatment for muscle invasive bladder cancer with loco-regional or metastatic spread had been fast tracked for approval by the FDA.  The standard of care for decades was cisplatin-based chemotherapy.  The new treatment was a combination of Keytruda and Padcev.

Keytruda is a PD-1 checkpoint inhibitor - which turns off a signal to T cells which keeps them from killing cancer cells and thereby boosts the body's immune reponse.  Padcev is representative of a new class of therapies - antibody drug conjuagates (ADC).  The antibody component of the ADC seeks out a protein (nectin 4) expressed by urothelial cell carcinoma.  It is linked to a cancer killing drug which is delivered to the cancer cell. 

In April 2023 - the combination was approved for locally advanced or metastatic muscle invasive bladder cancer for patients ineligible for cisplatin-based chemotherapy.  Results presented in October 2023 resulted in a application for accelerated approval as first-line treatment for all patients with locally advanced or metastatic.  The original target for approval was April of 2024 - but approval came on Dec 15, 2023.

I discussed this option with my medical oncologist and he supported this as my first line treatment.   We scheduled a treatment beginning in December - when I hoped that my Medicare Part B application I submitted in October would be approved.



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<![CDATA[Getting the word out]]>Wed, 26 Aug 2020 12:16:15 GMThttp://treffertinnovations.com/blog/getting-the-word-outI am serving as the local champion for the Great Cycle Challenge this year.  Local news station WBIR put together a nice piece to help spread the word.
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<![CDATA[SPREADING THE GOOD NEWS]]>Sat, 15 Aug 2020 22:48:30 GMThttp://treffertinnovations.com/blog/spreading-the-good-newsBicycling Magazine has a very nice article on my health journey.  A number of folks have found their way to my YouTube channel and have been inspired to begin their own health journeys!  This is precisely what I intended and I encourage all to reach out to me if they need advice, encouragement or simply want to share their success!

www.bicycling.com/news/a33532785/weight-loss-cycling-jon-treffert/

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<![CDATA[ButterFLY RIDE for ETCH]]>Sun, 02 Aug 2020 18:59:57 GMThttp://treffertinnovations.com/blog/butterfly-ride-for-etchThis month I am riding in the Butterfly Run to benefit East Tennessee Children's Hospital.  My page is here:   www.justgiving.com/fundraising/jon-treffert
iac_annual_report_2018-2019_final_reduced.pdf
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<![CDATA[REVERSING TYPE 2 DIABETES]]>Sat, 18 May 2019 15:04:08 GMThttp://treffertinnovations.com/blog/a-new-focus
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